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NGF exerts its biological effects by binding to its high-affinity tropomyosin receptor kinase A (TrkA), which activates pro-survival pathways including PI3K/AKT and MAPK/ERK, and its low-affinity p75 neurotrophin receptor (p75NTR), which can mediate pro-apoptotic signals (Rogdakis et al., 2022)

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